Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Pedigree Analysis01:35

Pedigree Analysis

Overview
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting extracellular collagen assembly to enhance functional recovery in composite neuromuscular trauma.

Connective tissue research·2026
Same author

CORR Insights®: Can Personalized 3D Kinematic Modeling Predict Loss of Pronation and Supination in Diaphyseal Forearm Malunions? A Clinical Validation Study.

Clinical orthopaedics and related research·2026
Same author

The epidemiology of elbow dislocation in the United States 2014-2023.

Journal of shoulder and elbow surgery·2026
Same author

Incidence of Carpal Tunnel Syndrome After the Diagnosis of Ulnar Neuropathy.

Journal of hand surgery global online·2026
Same author

Impact of Dialysis on Complication Rates Following Surgical Fracture Fixation in the Hand and Wrist.

Hand (New York, N.Y.)·2026
Same author

Validation of a Quick Carpal Tunnel Syndrome-6 Questionnaire as a Diagnostic Tool for Carpal Tunnel Syndrome.

Hand (New York, N.Y.)·2025
Same journal

The Diagnosis and Management of Clenched Fist Syndrome.

The Journal of hand surgery·2026
Same journal

Ultrasound-Assisted Thin Posteromedial Thigh Free Flap for Coverage of Hand and Upper-Extremity Wounds.

The Journal of hand surgery·2026
Same journal

Comparison of One- and Two-knot Techniques in Eight-Strand Flexor Tendon Repair Using Looped Sutures: A Biomechanical Study in a Porcine Model.

The Journal of hand surgery·2026
Same journal

Biomechanical Comparison of Metal Versus Suture and Screw Tension Band Technique for Olecranon Fractures.

The Journal of hand surgery·2026
Same journal

Incidence, Timing, and Predictors of Staged Contralateral Carpal Tunnel Release at Minimum Ten-Year Follow-Up from Unilateral Surgery.

The Journal of hand surgery·2026
Same journal

Upper Limb Reconstruction in Arthrogryposis Multiplex Congenita: A Systematic Review.

The Journal of hand surgery·2026
See all related articles

Related Experiment Video

Updated: May 19, 2026

An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
07:45

An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

Published on: October 21, 2014

Kienböck disease.

Kevin Lutsky1, Pedro K Beredjiklian

  • 1Department of Orthopaedic Surgery, Jefferson Medical College, Philadelphia, PA, USA.

The Journal of Hand Surgery
|August 25, 2012
PubMed
Summary
This summary is machine-generated.

Kienböck disease (osteonecrosis of the lunate) causes wrist pain. While traditional surgeries offer relief, newer bone grafting techniques may improve outcomes by aiding lunate revascularization.

More Related Videos

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Related Experiment Videos

Last Updated: May 19, 2026

An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
07:45

An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

Published on: October 21, 2014

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Area of Science:

  • Orthopedics
  • Hand Surgery
  • Radiology

Background:

  • Kienböck disease, or osteonecrosis of the lunate, is a poorly understood condition causing wrist pain and dysfunction.
  • Etiology is multifactorial, with proposed causes including anatomical, mechanical, vascular, and traumatic factors.
  • The natural history and correlation between clinical/radiographic findings remain unclear.

Purpose of the Study:

  • To review the current understanding of Kienböck disease.
  • To evaluate traditional and emerging surgical treatments for Kienböck disease.
  • To highlight areas requiring further research.

Main Methods:

  • Literature review of Kienböck disease etiology, natural history, and treatment options.
  • Analysis of traditional surgical interventions (radial shortening osteotomy, proximal row carpectomy).
  • Evaluation of newer techniques, including pedicled bone grafts for revascularization.

Main Results:

  • Traditional surgeries are reliable for pain relief and functional improvement.
  • Newer bone graft procedures show potential for lunate revascularization in early stages.
  • Further data is needed to confirm the superiority of newer techniques over traditional ones.

Conclusions:

  • Kienböck disease remains a complex challenge in hand surgery.
  • Nonsurgical management is the initial approach, but surgical outcomes require further investigation.
  • Pedicled bone grafts offer a promising avenue for arresting disease progression if validated by additional research.