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Related Concept Videos

Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Celiac disease.

Kate E Evans1, David S Sanders

  • 1Department of Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, South Yorkshire, UK. jan.tack@med.kuleuven.ac.be

Gastroenterology Clinics of North America
|August 25, 2012
PubMed
Summary
This summary is machine-generated.

Celiac disease affects 1% of people but is often missed. This review covers celiac disease understanding, diagnosis, and challenges, highlighting the need for further investigation in some patients despite a gluten-free diet.

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08:40

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Published on: September 22, 2019

Area of Science:

  • Gastroenterology
  • Immunology
  • Internal Medicine

Background:

  • Celiac disease is a prevalent autoimmune disorder affecting approximately 1% of the global population.
  • Despite its prevalence, celiac disease remains significantly underdiagnosed, leading to delayed or missed treatment.
  • This condition necessitates a comprehensive understanding of its pathophysiology and clinical manifestations.

Purpose of the Study:

  • To provide a comprehensive review of the current understanding of celiac disease.
  • To elucidate common diagnostic challenges and pitfalls associated with celiac disease identification.
  • To discuss management strategies and the implications of persistent symptoms in patients on a gluten-free diet.

Main Methods:

  • Literature review of recent studies on celiac disease.
  • Analysis of diagnostic criteria and serological markers.
  • Examination of clinical outcomes and treatment responses.

Main Results:

  • Celiac disease diagnosis relies on a combination of serology, genetic predisposition, and biopsy, though pitfalls exist.
  • A gluten-free diet is the primary treatment, but symptom persistence occurs in a subset of patients.
  • Further investigations are crucial for patients with ongoing symptoms despite adherence to a gluten-free diet.

Conclusions:

  • Improved awareness and diagnostic strategies are essential to reduce the underdiagnosis of celiac disease.
  • Recognizing diagnostic pitfalls can enhance timely and accurate patient identification.
  • Persistent symptoms warrant thorough evaluation to rule out other conditions or complications.