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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
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Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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Updated: May 19, 2026

An Enzyme- and Serum-free Neural Stem Cell Culture Model for EMT Investigation Suited for Drug Discovery
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Published on: August 23, 2016

Mesenchymal stem cells overexpressing PEDF decrease the angiogenesis of gliomas.

Qiaoshu Wang1, Zhaoyun Zhang2, Tianling Ding3

  • 1*Department of Neurology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.

Bioscience Reports
|August 25, 2012
PubMed
Summary
This summary is machine-generated.

Human mesenchymal stem cells (hMSCs) deliver pigment epithelium-derived factor (PEDF) to brain tumors, inhibiting growth and improving survival in glioma models. This novel approach shows promise for treating refractory brain tumors.

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Flow Cytometry-based Drug Screening System for the Identification of Small Molecules That Promote Cellular Differentiation of Glioblastoma Stem Cells

Published on: January 10, 2018

Area of Science:

  • Neuro-oncology
  • Stem Cell Therapy
  • Gene Therapy

Background:

  • Brain tumors, particularly gliomas, present significant therapeutic challenges.
  • Tumor angiogenesis is a critical process in glioma progression.
  • Developing targeted delivery systems for therapeutic agents is essential.

Purpose of the Study:

  • To evaluate the feasibility of using human mesenchymal stem cells (hMSCs) to deliver pigment epithelium-derived factor (PEDF) for treating intracranial gliomas.
  • To assess the migratory capacity of hMSCs in a glioma model.
  • To determine the therapeutic efficacy of hMSC-mediated PEDF delivery.

Main Methods:

  • Intracranial injection of hMSCs in a glioma model.
  • In vitro migration assays assessing the influence of vascular endothelial growth factor (VEGF) and PEDF on hMSC migration.
  • Systematic delivery of adeno-associated virus (AAV)-PEDF to established glioma xenografts.
  • Assessment of glioma apoptosis and survival rates in treated mice.

Main Results:

  • hMSCs demonstrated infiltration into vessel beds and distribution throughout the tumor.
  • VEGF enhanced hMSC migration, while PEDF inhibited it.
  • AAV-PEDF delivery led to increased glioma apoptosis.
  • Treatment with hMSCs delivering PEDF significantly prolonged the survival of mice bearing U87 gliomas.

Conclusions:

  • hMSCs can effectively migrate and deliver PEDF to target glioma cells.
  • The hMSC-PEDF system represents a novel and promising therapeutic strategy for refractory brain tumors.
  • This approach warrants further investigation for clinical application in neuro-oncology.