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Updated: May 19, 2026
08:01
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
Published on: February 28, 2017
Sending the right signal: Notch and stem cells
Carolina N Perdigoto1, Allison J Bardin
1Institut Curie, 26 rue d'Ulm, Paris F-75248, France.
Biochimica Et Biophysica Acta
|August 25, 2012
Summary
Notch signaling regulates adult stem cell fate decisions, including proliferation and differentiation, across various tissues like the intestine, skin, lungs, and blood. This pathway
Area of Science:
- Biochemistry
- Developmental Biology
- Cell Biology
Background:
- Notch signaling is crucial for development and adult stem cell regulation.
- It impacts stem cells in the intestine, skin, lungs, hematopoietic system, and muscle.
Purpose of the Study:
- To review molecular mechanisms of Notch component modulation.
- To introduce principles of Notch signaling in cell fate decisions.
- To illustrate Notch functions in major adult stem cell systems.
Main Methods:
- Review of molecular mechanisms and recent advances in Notch signaling.
- Description of fundamental principles of Notch signaling in cell fate decisions.
- Illustration of Notch functions in Drosophila and mammalian stem cell models.
Main Results:
- Notch receptor and ligands are regulated by endocytic processes.
- Glycosylation of Notch influences ligand interactions and receptor activity.
- Notch signaling controls cell fate decisions like proliferation and differentiation.
Conclusions:
- Notch signaling is vital for cell fate decisions in diverse adult stem cell types.
- Precise levels of Notch signaling are often required for specific cell fate outcomes.
- This review highlights Notch's role in stem cell biology across multiple tissues.
Related Concept Videos
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
01:26Stem Cell Niche
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
01:27Source And Potency Of Stem Cells
Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
01:01Regulation of Hematopoietic Stem Cells
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...