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Published on: January 19, 2016
Reversible thermal transition of polydiacetylene based on KTTKS collagen sequence
Pasquale Palladino1, Valeria Castelletto, Ashkan Dehsorkhi
1School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AD, UK.
Abstract:
Here we explore the physico-chemical properties of a peptide amphiphile obtained by chemical conjugation of the collagen-stimulating peptide KTTKS with 10,12-pentacosadiynoic acid which photopolymerizes as a stable and extended polydiacetylene. We investigate the self-assembly of this new polymer and rationalize its peculiar behavior in terms of a thermal conformational transition. Surprisingly, this polymer shows a thermal transition associated with a non-cooperative increase in β-sheet content at high temperature.
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