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Aiding and abetting roles of NOX oxidases in cellular transformation

Karen Block1, Yves Gorin

  • 1South Texas Veterans Health Care System, Audie L. Murphy Memorial Hospital Division, Department of Medicine, San Antonio, Texas 78229-73900, USA. block@uthscsa.edu

Nature Reviews. Cancer
|August 25, 2012
PubMed

Insights

NADPH oxidases (NOX) generate reactive oxygen species (ROS) crucial for cancer progression by influencing oncogenes and tumor suppressors. This review details NOX targets and signaling in cancer etiology.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • NADPH oxidases (NOX) are key enzymes generating reactive oxygen species (ROS).
  • ROS signaling pathways are implicated in cancer development and progression.
  • NOX enzymes regulate cellular functions at specific membrane microdomains.

Purpose of the Study:

  • To review the primary targets of NOX-derived ROS.
  • To elucidate redox-linked signaling systems influenced by NOX.
  • To discuss the role of NOX oxidases in cancer etiology.

Main Methods:

  • Literature review of NOX family enzymes.
  • Analysis of NOX-derived ROS signaling in cancer.
  • Examination of NOX interactions with oncogenes and tumor suppressors.

Main Results:

  • NOX enzymes activate oncogenes and inactivate tumor suppressor proteins.
  • NOX-derived ROS modulate critical redox-sensitive signaling pathways.
  • Specific NOX isoforms contribute to various stages of cancer development.

Conclusions:

  • NOX family enzymes play a significant role in cancer etiology.
  • Targeting NOX-derived ROS offers potential therapeutic strategies for cancer.
  • Understanding NOX-mediated signaling is crucial for cancer research.

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