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Related Experiment Video

Updated: May 19, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

Osteoprotegerin levels decrease during testosterone therapy in aging men and are associated with changed distribution

L Frederiksen¹, D Glintborg, K Højlund

¹Department of Endocrinology, Odense University Hospital, Odense, Denmark.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme

|August 25, 2012

Summary

This summary is machine-generated.

Testosterone therapy in aging men reduced osteoprotegerin (OPG) levels, a marker of cardiovascular risk. These changes were linked to fat distribution shifts, suggesting potential cardiovascular benefits.

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Area of Science:

Endocrinology
Cardiovascular Health
Aging Research

Background:

Cardiovascular effects of testosterone treatment remain debated.
Osteoprotegerin (OPG) is an established independent marker of cardiovascular risk.
Aging men with low testosterone levels may benefit from understanding OPG changes.

Purpose of the Study:

To investigate the impact of testosterone therapy on OPG levels in aging men with low normal bioavailable testosterone.
To explore the relationship between OPG changes and body composition alterations.

Main Methods:

Randomized, double-blinded, placebo-controlled study over 6 months.
38 men aged 60-78 years with specific testosterone and waist circumference criteria received testosterone gel or placebo.
Measurements included OPG, C-reactive protein (CRP), lean body mass (LBM), fat mass (total, visceral, subcutaneous), and bone mineral density (BMD).

Main Results:

Testosterone therapy decreased total fat mass and subcutaneous adipose tissue (SAT), but visceral adipose tissue (VAT) remained unchanged.
Osteoprotegerin (OPG) levels significantly decreased in the testosterone group compared to placebo.
In responders, OPG changes correlated inversely with SAT and positively with VAT changes.

Conclusions:

Testosterone therapy in aging men appears to decrease OPG levels, potentially indicating reduced cardiovascular risk.
The observed decrease in OPG is associated with alterations in regional fat distribution.
Further research is warranted to elucidate the association between OPG and regional fat mass distribution in this population.