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Related Experiment Video

Updated: May 19, 2026

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos
08:43

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

Published on: June 6, 2016

Maternal control of mouse preimplantation development.

Wenjing Zheng1, Kui Liu

  • 1Department of Cell and Molecular Biology, University of Gothenburg, Gothenburg, Sweden. wenjing.zheng@gu.se

Results and Problems in Cell Differentiation
|August 25, 2012
PubMed
Summary

Maternal factors control early mammalian development from egg to blastocyst. Understanding these factors and their interactions is key to deciphering the maternal regulatory network governing preimplantation embryogenesis.

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Area of Science:

  • Developmental Biology
  • Genetics
  • Epigenetics

Background:

  • Mammalian preimplantation development involves dedifferentiation from eggs to totipotent blastomeres and pluripotent blastocyst cells.
  • Maternal factors, accumulated during oogenesis, initially direct development until embryonic genome activation.
  • Maternal-effect genes encode crucial factors influencing early embryonic stages.

Purpose of the Study:

  • To summarize the known functions of maternal factors in mammalian preimplantation development.
  • To highlight the current understanding of maternal factor roles in embryogenesis.
  • To provide a foundation for understanding the maternal regulatory network.

Main Methods:

  • Review of existing literature on maternal factors in genetically modified mouse models.

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Last Updated: May 19, 2026

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos
08:43

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

Published on: June 6, 2016

Mouse In Vivo Placental Targeted CRISPR Manipulation
07:39

Mouse In Vivo Placental Targeted CRISPR Manipulation

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  • Analysis of characterized maternal factors and their roles.
  • Synthesis of information on maternal factor functions.

    • Main Results:

    • Maternal factors are essential for processes including macromolecule degradation, epigenetic modification, protein translation, signaling, and cell compaction.
    • Despite characterization, interactions between different maternal factors remain largely unknown.
    • Known maternal factors play diverse and critical roles in early development.

    Conclusions:

    • A comprehensive understanding of maternal factors is crucial for elucidating the maternal regulatory network.
    • Further research into the interactions between maternal factors will enhance our knowledge of preimplantation embryogenesis.
    • The summarized functions provide insights into the complex regulation of early mammalian development.