Imaging limbal and scleral vasculature using Swept Source Optical Coherence Tomography

Area of Science:

• Ophthalmology
• Biomedical Imaging
• Medical Devices

Background:

• Vascularization in the anterior segment of the human eye is crucial for ocular health.
• Non-invasive imaging techniques are needed for detailed visualization of these delicate structures.
• Current methods may lack the speed and resolution for comprehensive vascular mapping.

Purpose of the Study:

• To demonstrate the application of high-speed swept source optical coherence tomography (SS-OCT) for in vivo vessel visualization.
• To generate 3D depth-resolved vasculature maps of the human corneo-scleral junction and sclera.
• To assess the vascular network in the conjunctiva and episclera.

Main Methods:

• Utilized a swept source OCT system operating at a 1050nm wavelength range.
• Employed a high A-scan rate of 100kHz to achieve high imaging speed.
• Performed in vivo imaging of the human corneo-scleral junction and sclera.

Main Results:

• Achieved high-speed imaging, enabling the generation of 3D depth-resolved vasculature maps.
• Successfully visualized the vascular system in the conjunctiva and episclera.
• Demonstrated the capability of SS-OCT for detailed anterior segment vascular imaging.

Conclusions:

• High-speed SS-OCT is a powerful tool for in vivo visualization of ocular vasculature.
• The technique provides detailed 3D vascular maps, offering insights into conjunctival and episcleral vascularization.
• This method holds potential for research and clinical applications in ophthalmology.