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Genetic predisposition for dermal problems in hexavalent chromium exposed population.

Priti Sharma¹, Vipin Bihari, Sudhir K Agarwal

¹Petroleum Toxicology Division, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226001, India.

Journal of Nucleic Acids

|August 25, 2012

Summary

Genetic susceptibility influences skin problems from hexavalent chromium (Cr(VI)) exposure. Individuals with a GSTM1 null genotype showed increased susceptibility to dermal adversities in Cr(VI) contaminated areas.

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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Published on: December 19, 2019

Area of Science:

Environmental Health
Genetics
Dermatology

Background:

Hexavalent chromium (Cr(VI)) contamination in groundwater poses health risks.
Kanpur, India, has elevated Cr(VI) levels, necessitating health impact studies.
Genetic factors may influence individual susceptibility to environmental toxins.

Purpose of the Study:

To investigate the role of genetic susceptibility in hexavalent chromium-induced dermal adversities.
To compare genetic polymorphisms between symptomatic and asymptomatic individuals exposed to Cr(VI).
To identify specific gene variations associated with increased risk of skin problems in contaminated areas.

Main Methods:

Population health status examined in Kanpur, India, with high groundwater Cr(VI).
DNA collected for polymorphic determination of NQO1, hOGG1, GSTT1, and GSTM1 genes.
Symptomatic exposed (n=38), asymptomatic exposed (n=108), and asymptomatic controls (n=148) were compared.

Main Results:

GSTM1 null genotype was more prevalent in symptomatic exposed subjects (36.8%) versus asymptomatic exposed (19.4%).
GSTM1 null genotype significantly increased susceptibility to dermal adversities (OR=2.42; 95% CI=1.071-5.451).
No confounding effects found for age, smoking, gender, or duration of residence; other gene associations were not significant.

Conclusions:

Polymorphisms in the GSTM1 gene may influence dermal outcomes in residents of Cr(VI) contaminated areas.
GSTM1 null genotype is a potential risk factor for developing skin issues upon Cr(VI) exposure.
Further research is needed across diverse populations to validate these findings.