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Defense and adaptation: the complex inter-relationship between Campylobacter jejuni and mucus
Abofu Alemka1, Nicolae Corcionivoschi, Billy Bourke
1Department of Biological Sciences, University of Alberta Edmonton, AB, Canada.
Frontiers in Cellular and Infection Microbiology
|August 25, 2012
Summary
Campylobacter jejuni (C. jejuni) infection relies on mucus colonization. This review explores how C. jejuni adapts to intestinal mucus, influencing its pathogenicity in different hosts.
Area of Science:
- Microbiology
- Infectious Diseases
- Host-Pathogen Interactions
Background:
- Mucus colonization is critical for mucosal pathogens.
- Specific mucin types and modifications influence host protection against Campylobacter jejuni.
- Campylobacter jejuni exhibits adaptations for intestinal mucus colonization.
Purpose of the Study:
- To review recent advances in understanding the interaction between Campylobacter jejuni and the mucus layer.
- To explore how C. jejuni adapts to colonize intestinal mucus.
- To examine the role of mucins in modulating C. jejuni pathogenicity.
Main Methods:
- Literature review of recent studies on Campylobacter jejuni and mucus.
- Analysis of mechanisms by which C. jejuni interacts with mucus components.
- Examination of species-specific differences in mucin-pathogen interactions.
Main Results:
- Mucus components are chemotactic for C. jejuni.
- Mucus rheology aids C. jejuni motility.
- Mucins influence C. jejuni pathogenicity in a species-specific manner, determining disease or commensalism.
Conclusions:
- Campylobacter jejuni possesses sophisticated adaptations to colonize intestinal mucus.
- The interplay between C. jejuni and mucins dictates its pathogenic potential.
- Understanding these interactions is key to controlling C. jejuni infections.
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