Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Decrease of singlet oxygen chemiluminescence by the presence of carnosine].

A G Svachko, V E Formaziuk, V I Sergienko

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |August 1, 1990
    PubMed
    Summary

    Certain antirheumatic and antioxidant compounds, including Voltaren and Carnosine, effectively reduce singlet oxygen production. This finding is significant for understanding oxidative stress in diseases like atherosclerosis and cataracts.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Constructing of Synthetic DNA-Histone Networks as Extracellular Trap Model for Biomedical Research.

    Bulletin of experimental biology and medicine·2025
    Same author

    Hypochlorous Acid-Modified Serum Albumin Causes NETosis in the Whole Blood Ex Vivo and in Isolated Neutrophils.

    Bulletin of experimental biology and medicine·2024
    Same author

    The Effect of Vitamin D3 on Neutrophil Extracellular Trap Formation in High-Glucose Conditions.

    Bulletin of experimental biology and medicine·2024
    Same author

    Antiplatelet Action of Chloramine Derivatives of Adenosine Phosphates and Their Chemical Activity in Relation to Sulfur-Containing Compounds.

    Bulletin of experimental biology and medicine·2023
    Same author

    Hyperglycemia and Some Aspects of Leukocyte Activation In Vitro.

    Bulletin of experimental biology and medicine·2021
    Same author

    Optical properties and electronic structure of Eu(III) complexes with HMPA and TPPO.

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2021

    Area of Science:

    • Biochemistry
    • Pharmacology
    • Oxidative Stress Research

    Background:

    • Active oxygen species, particularly singlet oxygen, are implicated in biomembrane destruction.
    • This oxidative damage is a potential mechanism underlying various diseases, including atherosclerosis and cataracts.
    • Investigating compounds that can mitigate singlet oxygen production is crucial for therapeutic development.

    Purpose of the Study:

    • To evaluate the antiradical efficacy of specific compounds by measuring their effect on singlet oxygen chemiluminescence.
    • To identify which tested medications possess singlet oxygen quenching properties.

    Main Methods:

    • Chemical generation of singlet oxygen using sodium hypochlorite (NaClO) and hydrogen peroxide (H2O2).
    • Quantification of singlet oxygen production via chemiluminescence measurements.

    Related Experiment Videos

  • Assessment of the impact of various compounds (Japanese Catalin, Chinese Baineiting, Voltaren, Finnish Catachrome, Carnosine, American Quinax) on singlet oxygen chemiluminescence.

    • Main Results:

    • Japanese Catalin, Chinese Baineiting, Voltaren, Finnish Catachrome, and Carnosine demonstrated a decrease in singlet oxygen chemiluminescence.
    • Voltaren, an antirheumatic drug, showed significant antiradical activity.
    • American Quinax did not exhibit any effect on singlet oxygen production.
    • The tested compounds varied in their potency in reducing singlet oxygen levels.

    Conclusions:

    • Several tested compounds, including Voltaren and Carnosine, possess antiradical properties by reducing singlet oxygen formation.
    • These findings suggest a potential therapeutic role for these compounds in conditions associated with oxidative stress.
    • Further research is warranted to explore the mechanisms and clinical applications of these singlet oxygen-scavenging agents.