[Changes in fatty acid composition and lipid peroxidation activity in microsomal membranes of the liver in...

The experiments on rats have shown, that coronary artery ligation caused distinct alteration in fatty acids composition of microsomal lipids of the liver during restoration period. Within 7-21 days after artery ligation content of fatty acids saturated was increased, but concentration of arachidonic acid was decreased. In this period affinity of the fluorescent probe ANS to microsomal membranes and affinity of the cytochrome P-450 to aniline was significantly decreased. Stability of the cytochrome P-450 to impairment during lipid peroxidation induction in vitro within 7-14 days myocardial infarction was increased. However in 21 day stability of cytochrome P-450 was significantly decreased.