[Action of colchicine on analgetic effects of morphine and DADLE in rats]

Intracerebroventricular injection of morphine and DADL significantly increased the tail-flick latency in the rat (full analgesia during 1.5-2.5 hours). Previous i. c. v. (lateral ventriculus) injection of colchicine prevented the analgetic effects of these drugs during 5 +/- 1 weeks with subsequent recovery.