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Published on: March 25, 2016
Function of granulocytes in B-chronic lymphatic leukaemia
D Dekaris1, S Handl, A Sabioncello
1Institute of Immunology, University of Zagreb, Yugoslavia.
Blut
|December 1, 1990
Summary
Granulocyte function in B-cell chronic lymphatic leukaemia (B-CLL) patients showed decreased spontaneous mobility. However, other functions remained comparable, with no stage correlation, but reduced digestion in treated patients.
Area of Science:
- Immunology
- Hematology
- Oncology
Background:
- B-cell chronic lymphatic leukaemia (B-CLL) is a heterogeneous lymphoproliferative disorder.
- The role of granulocytes in B-CLL pathogenesis and immune evasion is not fully understood.
- Granulocytes are key innate immune cells with diverse functions.
Purpose of the Study:
- To investigate the functional status of granulocytes in patients with B-CLL.
- To assess spontaneous mobility, phagocytosis, digestion, and antibody-dependent cellular cytotoxicity (ADCC) of B-CLL granulocytes.
- To correlate granulocyte function with clinical staging and treatment status in B-CLL.
Main Methods:
- Granulocytes were isolated from peripheral blood of 48 B-CLL patients and 35 healthy controls.
- Functional assays included spontaneous mobility, ingestion, digestion, and ADCC.
- Comparison between patient groups (treated vs. untreated) and correlation with clinical stages were performed.
Main Results:
- Granulocytes from B-CLL patients exhibited significantly decreased spontaneous mobility compared to controls.
- No significant differences were observed in granulocyte ingestion, digestion, or ADCC between B-CLL patients and controls.
- Granulocyte function alterations did not correlate with B-CLL clinical stages.
- Treated B-CLL patients (chlorambucil, steroids) showed a significant decrease in granulocyte digestion compared to untreated patients.
Conclusions:
- Granulocyte dysfunction, specifically reduced spontaneous mobility, is present in B-cell chronic lymphatic leukaemia.
- Treatment with chlorambucil and steroids may further impair granulocyte digestive capacity in B-CLL patients.
- These findings highlight potential immune dysregulation involving granulocytes in B-CLL and the impact of therapy.
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