Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antidepressant Drugs: Overview

Antidepressant Drugs: Overview

Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...

Antidepressant Drugs: MAOIs and Other Agents

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...

G-protein Coupled Receptors

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Stress and Mental Health

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prevalence of Viral Hepatitis Antibodies Among Alcoholics in Croatia: A Single Center's Results.

Antibodies (Basel, Switzerland)·2026

Same author

Revisiting Rosacea Through the Skin-Gut-Brain Axis: A Neuroimmune Perspective.

Life (Basel, Switzerland)·2026

Same author

MTHFR and MTRR Polymorphisms Predict Sex-Dependent Psychotic Symptom Improvements, Not Metabolic Changes.

International journal of molecular sciences·2026

Same author

The Impact of ADHD Symptoms on Children's Oral Health.

Acta stomatologica Croatica·2025

Same author

Thalamic hyperperfusion in early schizophrenia: Associations with cognitive deficits and negative symptoms.

Schizophrenia research·2025

Same author

Rethinking Lithium Monitoring: Insights from a Comparative Analysis of Saliva, Plasma, and Erythrocytes.

Neuropsychobiology·2025

Search research articles

Related Experiment Video

Updated: May 19, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

Connection between inflammatory markers, antidepressants and depression.

Danijel Crnković¹, Danijel Buljan, Dalibor Karlović

¹University Department of Psychiatry, Sestre milosrdnice University Hospital Center, Zagreb, Croatia. danijel.crnkovic@zg.t-com.hr

Acta Clinica Croatica

|August 28, 2012

Summary

Inflammatory markers like C-reactive protein (CRP) are elevated in major depressive disorder (MDD). Antidepressant therapy reduced CRP levels, suggesting inflammation plays a role in depression.

More Related Videos

Animal Models of Depression - Chronic Despair Model (CDM)

Animal Models of Depression - Chronic Despair Model (CDM)

Published on: September 23, 2021

Related Experiment Videos

Last Updated: May 19, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

Animal Models of Depression - Chronic Despair Model (CDM)

Animal Models of Depression - Chronic Despair Model (CDM)

Published on: September 23, 2021

Area of Science:

Psychiatry and Immunology

Background:

Major Depressive Disorder (MDD) is a prevalent mental health condition.
The role of inflammation in the pathophysiology of depression is increasingly recognized.

Purpose of the Study:

To investigate the association between inflammatory markers and MDD.
To explore the impact of antidepressant therapy on these markers.

Main Methods:

Quantified concentrations of C-reactive protein (CRP), interleukin-6, and tumor necrosis factor alpha.
Compared marker levels in MDD patients versus healthy controls.
Assessed changes in CRP levels before and after one-month antidepressant therapy in MDD patients.

Main Results:

MDD patients exhibited significantly higher concentrations of CRP, interleukin-6, and tumor necrosis factor alpha compared to healthy controls.
CRP levels were significantly reduced in MDD patients following one month of antidepressant therapy.

Conclusions:

Elevated inflammatory markers are associated with major depressive disorder.
Antidepressant therapy may exert its effects, in part, by modulating inflammatory processes, specifically reducing CRP levels.