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Updated: May 19, 2026
07:23
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
[Long non-coding RNAs and their relevance in cancer]
J Sána1, P Faltejsková, M Svoboda
1CEITEC- Stredoevropsky techologicky institut, Brno.
Summary
Long non-coding RNAs (lncRNAs) are key regulators of gene expression. This review highlights their diverse functions, particularly their roles in cancer biology and potential for translational oncology research.
Area of Science:
- Genomics
- Molecular Biology
- RNA Biology
Context:
- Eukaryotic genomes contain numerous non-coding DNA sequences.
- These sequences are transcribed into long non-coding RNAs (lncRNAs), which play regulatory roles.
- lncRNAs are involved in development and in response to external stimuli.
Purpose:
- To review novel classes of lncRNAs.
- To describe the biological functions of lncRNAs.
- To emphasize the roles of lncRNAs in tumor biology and translational oncology.
Summary:
- Long non-coding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides, transcribed from eukaryotic genomes.
- Despite sequence complexity hindering research, lncRNAs are crucial for transcriptional and post-transcriptional gene regulation.
- Over 3,300 lncRNAs have been identified, with many deregulated in human cancers, suggesting a role in carcinogenesis.
Impact:
- lncRNAs represent a significant area for understanding gene regulation.
- Their dysregulation in cancer highlights their importance in oncogenesis.
- Further characterization of functional lncRNAs is crucial for advancing translational oncology.
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02:39lncRNA - Long Non-coding RNAs
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
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01:23Types of RNA
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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02:53Ribosomal RNA Synthesis
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...