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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
Published on: April 7, 2021
Acute respiratory failure and intensive measures
1Division of Critical Care, Grady Memorial Hospital, Emory University, 80 Jesse Hill Jr. Drive SE, Atlanta, GA 30303, USA. bmclean1@gmh.edu
Abstract:
Critical patients presenting with acute respiratory failure (ARF) offer a plentiful, dynamic, and complex picture, which requires a deep understanding of gas exchange, pulmonary dynamics, and mechanical ventilation strategies. The most frequent cause of ARF is chronic disease with exacerbation. Interventions treating acute exacerbation, along with ventilatory support, physical therapy, and evidence-based strategies, may improve immediate outcomes. However, follow-up is essential and for the chronic obstructive pulmonary disease patient the goal is to avoid relapse or rehospitalization. This article discusses the evaluation of gas exchange failures, pulmonary mechanics, and the properties of obstructive airway disease as they relate to ARF.
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