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Updated: May 19, 2026

The Identification of Sea Lamprey Pheromones Using Bioassay-Guided Fractionation
Published on: July 17, 2018
Phorone A and isophorbasone A, sesterterpenoids isolated from the marine sponge Phorbas sp
Weihong Wang1, Yehee Lee, Tae Gu Lee
1Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, and Research Institute of Oceanography, Seoul National University, NS-80, Seoul, 151-747, Korea.
Abstract:
A chemical investigation of a Korean marine sponge, Phorbas sp., yielded unprecedented sesterterpenoids phorone A (1) and isophorbasone A (2) along with ansellone B (3) and phorbasone A acetate (4). Their complete structures were elucidated by the combination of spectroscopic data and chemical manipulation. Phorone A (1) and isophorbasone A (2) have the new "phorane"(5) and "isophorbasane"(6) sesterterpenoid carbon skeletons, respectively. Ansellone B (3) and phorbasone A acetate (4) exhibited potent inhibitory activity on nitric oxide production in RAW 264.7 LPS-activated mouse macrophage cells with IC(50) values of 4.5 and 2.8 μM, respectively.
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