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The variability and complexity of ameloblastoma: carcinoma ex ameloblastoma or primary ameloblastic carcinoma
Zitong Lin1, Fei Chen, Tiemei Wang
1Department of Dentomaxillofacial Radiology, Affiliated Stomatology Hospital of Medical School, Nanjing University, Zhong Yang Road 30, Nanjing, China.
Abstract:
Ameloblastoma is characterized by slow-growing, local invasiveness and high incidence of local recurrence. It usually presents with a benign histological appearance. However, ameloblastoma occasionally demonstrates a clinical course that is characteristic of malignant transformation. Here, we present a case of ameloblastoma with an aggressive clinical course, including multiple recurrences, a short disease-free interval, pulmonary metastasis and extensive skull-base infiltration. With a careful re-evaluation of the histology and cytology of the specimens of primary and recurrent ameloblastoma in 2006 and 2007, malignant transformation was observed and carcinoma ex ameloblastoma was ultimately diagnosed.
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