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Comprehensive review on oral disintegrating films
T Nagaraju1, R Gowthami, M Rajashekar
1Department of Pharmaceutics, Vaagdevi College of Pharmacy, Warangal, India.
Current Drug Delivery
|August 28, 2012
Summary
Oral disintegrating films (ODFs) offer a rapid drug delivery alternative for patients with swallowing difficulties. This technology bypasses first-pass metabolism for improved therapeutic outcomes.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Fast-dissolving drug delivery systems emerged in the 1970s to address challenges with traditional oral dosage forms.
- Orally disintegrating tablets (ODTs) were developed to disintegrate rapidly in the mouth without water.
Purpose of the Study:
- To review the advancements in oral drug delivery, focusing on oral disintegrating films (ODFs).
- To detail the materials, manufacturing, technologies, evaluation, and marketed products of ODFs.
Main Methods:
- Literature review of oral disintegrating film technology.
- Analysis of materials, manufacturing processes, and evaluation techniques for ODFs.
Main Results:
- ODFs utilize water-dissolving polymers for rapid disintegration and oromucosal absorption.
- This technology offers an alternative route for drugs subject to first-pass metabolism.
Conclusions:
- Oral disintegrating films represent a significant evolution in oral drug delivery.
- ODFs provide a convenient and effective method for drug administration, particularly for specific patient populations and drugs.
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