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A fatal intoxication case involving ropinirole.

Sébastien Duband¹, Carolyne Bidat, Yvan Gaillard

¹Department of Forensic Pathology, University Hospital of Saint-Etienne, Bellevue Hospital, 42055 Saint-Etienne Cedex 2, France. sebastien.duband@chu-st-etienne.fr

Journal of Forensic and Legal Medicine

|August 28, 2012

Summary

This case report details a fatal ropinirole intoxication. The peripheral blood ropinirole concentration of 64 ng/mL, combined with alcohol, was determined as the cause of death.

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Area of Science:

Forensic Toxicology
Pharmacology

Background:

Ropinirole is a dopamine agonist used for Parkinson's disease and restless legs syndrome.
Therapeutic plasma levels are typically 0.4–6 ng/mL.
Lethal ropinirole concentrations are not well-documented.

Observation:

A 37-year-old male was found deceased with no apparent autopsy cause of death.
Toxicological analysis detected ropinirole, paracetamol, and alcohol.

Findings:

Peripheral blood ropinirole concentration was 64 ng/mL.
Vitreous humor, urine, and bile showed ropinirole levels of 11, 2670, and 826 ng/mL, respectively.
Paracetamol levels were below 2 μg/mL.

Implications:

This case provides data on potentially lethal ropinirole concentrations.
Ropinirole intoxication, especially with alcohol, can be fatal.
Highlights the importance of comprehensive toxicological screening in unexplained deaths.