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[Use of regulatory T cells in cellular therapies in autoimmune diseases]

Guilaine Boursier1, Aurélie Siri, Hubert de Boysson

  • 1UMPC Université Paris 6, Master sciences et technologies, mention biologie moléculaire et cellulaire, parcours immunotechnologies et biothérapies, Paris 6 (PRES Sorbonne Universités), 4, place Jussieu, 75005 Paris, France. gboursier@gmail.com

Medecine Sciences : M/S
|August 28, 2012
PubMed

Self tolerance is dependent on regulatory T cells (Treg) which suppress effector T cells, avoiding autoimmunity. Functional and quantitative deficits of Treg have been reported in autoimmune diseases. A new therapeutic approach consisting in Treg adoptive transfer has proved to be efficient and safe in murine models. Two populations seem to be available for a clinical application: CD4(+)CD25(+)Foxp3(+) natural Treg derived from the thymus and induced regulatory T cells. First clinical trials have been applied to patients with autoimmune diseases. Classical treatments of autoimmune diseases are usually non-curative and require long-term administration. Treg cellular therapy may have a long-term effect and offers an alternative attractive approach.

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