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Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea

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Published on: November 9, 2016

Sonic aerosol therapy to target maxillary sinuses.

M Durand¹, S Le Guellec, J Pourchez

¹Service d'ORL et chirurgie cervico-faciale, centre hospitalier Émile-Roux, Le Puy-en-Velay, France. marc.durand@ch-lepuy.fr

European Annals of Otorhinolaryngology, Head and Neck Diseases

|August 28, 2012

Summary

A novel sonic nebulizer (NL11SN) with 100Hz sound improves drug deposition in nasal and paranasal sinuses. This technology enhances sinus ventilation and delivers therapeutic antibiotic concentrations in vitro.

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Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols

Published on: May 20, 2016

Area of Science:

Otolaryngology
Drug Delivery Systems
Medical Acoustics

Background:

Intranasal aerosol drug delivery is common in ENT practice.
Intranasal nebulization offers potential for targeted local drug delivery beyond the nasal valve.
The sonic nebulizer NL11SN uses 100Hz sound to potentially enhance nasal and sinus deposition.

Purpose of the Study:

Evaluate the in vivo effect of 100Hz sound on sinus ventilation and aerosol deposition.
Assess nasal and pulmonary aerosol deposition in healthy volunteers.
Quantify in vitro aerosol deposition in maxillary sinuses using a human head model.

Main Methods:

In vivo scintigraphy of (81m)Kr gas ventilation and (99m)Tc-DTPA aerosol deposition with NL11SN in 7 volunteers.
In vitro nebulization of gentamicin with NL11SN (with/without 100Hz sound) in a plastinated head model.
Quantification of gentamicin in paranasal sinuses via fluorescence polarization immunoassay.

Main Results:

100Hz sound associated with (81m)Kr gas improved paranasal sinus ventilation.
(99m)Tc-DTPA deposition was primarily in nasal cavities (2/3) vs. lungs (1/3).
In vitro, sonic mode NL11SN increased gentamicin deposition threefold in sinuses (P<0.002), achieving therapeutic levels.

Conclusions:

The NL11SN nebulizer effectively targets nasal cavities and maxillary sinuses.
The addition of 100Hz sound enhances aerosol deposition and sinus ventilation.
Sonic nebulization shows promise for effective local drug delivery to paranasal sinuses.