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Comparative genomics between fly, mouse, and cattle identifies genes associated with sire conception rate

G Li1, F Peñagaricano, K A Weigel

  • 1College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.

Journal of Dairy Science
|August 28, 2012
PubMed
Summary

Genomic analysis identified key genes, including MAP1B and PPP1R11, significantly associated with bull fertility. This research highlights the value of comparative genomics in understanding and improving male reproductive performance in cattle.

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...