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Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
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Published on: October 10, 2020

The glutathione-S-transferase mu 1 (GSTM1) null genotype and increased neutrophil response to low-level ozone (0.06

Neil E Alexis, John C Lay, Haibo Zhou

    The Journal of Allergy and Clinical Immunology
    |August 28, 2012
    PubMed
    Abstract

    No abstract available in PubMed .

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    Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...
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