Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Antigen Processing Pathways01:31

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
What is the Immune System?01:38

What is the Immune System?

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemokine receptor expression defines a trajectory from monocytes to mature macrophages in the lung.

Journal of leukocyte biology·2026
Same author

Pharmacological and Genetic Targeting of Inflammatory Chemokine Receptors CCR1, CCR2, and CCR5 in Atherosclerosis: A Systematic Review and Meta-Analysis of Preclinical Studies.

Journal of the American Heart Association·2026
Same author

CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity.

Mucosal immunology·2025
Same author

Generation of stable advective-diffusive chemokine gradients in a three-dimensional hydrogel.

AIP advances·2025
Same author

Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza.

Mucosal immunology·2025
Same author

Correction: CCR1 and CCR2 Coexpression on Monocytes Is Nonredundant and Delineates a Distinct Monocyte Subpopulation.

Journal of immunology (Baltimore, Md. : 1950)·2024
Same journal

IL-33 scripts cancer immunity.

Trends in immunology·2026
Same journal

Mitochondrial Ca<sup>2+</sup> signaling: A metabolic rheostat defining tumor and immune cell fate.

Trends in immunology·2026
Same journal

Cross-priming underlies the efficacy of antibody-drug conjugates and immunotherapy combinations.

Trends in immunology·2026
Same journal

Gut microbiome metabolites meet immunometabolism in inflammatory bowel disease.

Trends in immunology·2026
Same journal

Metabolic regulatory nodes of the inflammasome and inflammatory cell death.

Trends in immunology·2026
Same journal

Parental leave in immunology - 6.

Trends in immunology·2026
See all related articles

Related Experiment Video

Updated: May 19, 2026

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
09:55

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

Published on: February 3, 2022

D6: the 'crowd controller' at the immune gateway.

Kit Ming Lee1, Robert J B Nibbs, Gerard J Graham

  • 1Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Trends in Immunology
|August 28, 2012
PubMed
Summary
This summary is machine-generated.

The chemokine receptor D6 prevents inflammatory leukocytes from blocking lymphatic vessels, ensuring proper fluid and immune cell flow. Its absence impairs inflammation resolution by congesting the lymphatic system.

More Related Videos

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens
06:03

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens

Published on: September 20, 2024

Related Experiment Videos

Last Updated: May 19, 2026

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
09:55

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

Published on: February 3, 2022

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens
06:03

Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens

Published on: September 20, 2024

Area of Science:

  • Immunology
  • Inflammation research
  • Lymphatic system function

Background:

  • The chemokine receptor D6 (also known as Ccrel1) is recognized for its role in resolving inflammatory responses.
  • Emerging evidence suggests D6 also plays a critical part in integrating innate and adaptive immune system activities.

Purpose of the Study:

  • To investigate the proposed function of D6 in preventing inflammatory leukocyte adhesion to lymphatic vasculature.
  • To elucidate the mechanism by which D6 deficiency leads to impaired inflammation resolution.

Main Methods:

  • Utilized D6-deficient mouse models to observe leukocyte behavior and lymphatic function during inflammation.
  • Analyzed fluid and cellular transport dynamics within the lymphatic system of wild-type versus D6-deficient mice.
  • Assessed antigen presentation efficiency in the context of lymphatic congestion.

Main Results:

  • D6 deficiency resulted in significant accumulation of inflammatory leukocytes around lymphatic endothelial cells.
  • This leukocyte buildup led to congestion of the lymphatic system, hindering fluid and cell drainage from inflamed tissues.
  • Impaired lymphatic drainage in D6-deficient mice compromised antigen presentation to adaptive immune cells.

Conclusions:

  • D6 is crucial for maintaining lymphatic vessel patency during inflammation by preventing leukocyte aggregation.
  • The impaired resolution of inflammation in D6-deficient mice is likely due to compromised lymphatic fluid and cellular transport.
  • This study presents a unified model for D6 function, linking its role in innate immunity, lymphatic drainage, and adaptive immune responses.