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Updated: May 19, 2026
Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
Published on: July 27, 2022
[Radiation-induced proctitis: symptoms, pathophysiology and treatment].
C Kintzinger1, C Demoor-Goldschmidt, R Abderrahmani
1Service de radiothérapie, groupe hospitalier Sud-Réunion Terre-Sainte, Saint-Pierre, La Réunion.
Radiotherapy for pelvic tumors can cause radiation proctitis, a complex side effect. This review covers prevention, detection, and treatment of radiation proctitis for improved patient care.
Area of Science:
- Oncology
- Radiation Oncology
- Gastroenterology
Context:
- Pelvic radiotherapy is a primary treatment for various cancers.
- Radiation therapy can lead to significant acute and long-term side effects.
- Radiation proctitis is a notable complication impacting patient quality of life.
Purpose:
- To provide a comprehensive review of radiation proctitis.
- To discuss the management of radiation proctitis following pelvic cancer treatment.
- To consolidate information on prevention, detection, and treatment strategies.
Summary:
- Radiotherapy for pelvic malignancies carries a risk of developing radiation proctitis.
- Effective management involves preventive strategies (clinical and dosimetric), early detection, and appropriate medical or surgical interventions.
- Patient support is crucial throughout the treatment course and long-term follow-up.
Impact:
- This review aims to enhance clinical understanding and management of radiation proctitis.
- Improved strategies can mitigate treatment-related morbidity and improve outcomes for cancer survivors.
- Highlights the importance of multidisciplinary care in managing radiation-induced gastrointestinal toxicity.
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