Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Coronary Artery Disease I: Introduction

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...

Coronary Artery Disease IV: Preventive Measures

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...

Coefficient of Correlation

Coefficient of Correlation

The correlation coefficient, r, developed by Karl Pearson in the early 1900s, is numerical and provides a measure of strength and direction of the linear association between the independent variable x and the dependent variable y.
If you suspect a linear relationship between x and y, then r can measure how strong the linear relationship is.
What the VALUE of r tells us:
The value of r is always between –1 and +1: –1 ≤ r ≤ 1.
The size of the correlation r indicates the strength of the linear...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Youth Mental Health in Vulnerable Communities: Barriers, Facilitators, and Place-Based Solutions-A Situational Analysis from England's Southeast Coast.

Journal of prevention (2022)·2026

Same author

"We Are Humans, and We Are People" - A Thematic Analysis Exploring the Disclosure and Help-Seeking Experiences of Young People Who Experience Voice-Hearing Within Mental Health Services in the UK.

Clinical child psychology and psychiatry·2025

Same author

Are measures of voice hearing distinct from measures of emotional states, recovery and well-being? A factor analysis study.

PloS one·2025

Same author

Weaving knowledge systems to eradicate drinking water crises in First Nations across Canada.

Journal of water and health·2025

Same author

Multiple Left Ventricular Ball Thrombi in a Patient With Nonischemic Cardiomyopathy Bridged to Heart-Lung Transplantation.

JACC. Case reports·2025

Same author

Team-based motivational engagement intervention in young people with first-episode psychosis: the EYE-2 cluster RCT with economic and process evaluation.

Health and social care delivery research·2025

Search research articles

Related Experiment Video

Updated: May 19, 2026

Semi-Automatic Graphical Tool for Measuring Coronary Artery Spatially Weighted Calcium Score from Gated Cardiac Computed Tomography Images

Semi-Automatic Graphical Tool for Measuring Coronary Artery Spatially Weighted Calcium Score from Gated Cardiac Computed Tomography Images

Published on: September 22, 2023

Correlation between coronary plaque burden and heart weight.

Mingchang Zhang¹, Julia Shields, Yang Zhang

¹Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai, China.

Pathology, Research and Practice

|August 28, 2012

Summary

The extent of coronary atherosclerosis, or hardening of the arteries, is linked to increased heart muscle mass (cardiomegaly). This association holds true even when considering factors like age and body mass index in sudden cardiac death cases.

More Related Videos

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

Related Experiment Videos

Last Updated: May 19, 2026

Semi-Automatic Graphical Tool for Measuring Coronary Artery Spatially Weighted Calcium Score from Gated Cardiac Computed Tomography Images

Semi-Automatic Graphical Tool for Measuring Coronary Artery Spatially Weighted Calcium Score from Gated Cardiac Computed Tomography Images

Published on: September 22, 2023

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

Area of Science:

Cardiology
Pathology
Public Health

Background:

Coronary atherosclerosis is a leading cause of death worldwide.
The relationship between coronary artery disease severity and cardiac hypertrophy is not fully understood.
Sudden coronary death provides a unique population to study these associations.

Purpose of the Study:

To investigate the association between the extent of coronary atherosclerosis and cardiac hypertrophy.
To determine if coronary artery disease severity correlates with increased heart muscle mass in sudden cardiac death victims.

Main Methods:

Retrospective review of autopsy reports from sudden coronary deaths.
Quantification of coronary artery disease by the number of narrowed epicardial arteries.
Assessment of cardiomegaly using a height-based scoring system (0-4).

Main Results:

Significant correlation found between the extent of coronary atherosclerosis and cardiomegaly.
Multivariate analysis revealed positive associations of body mass index, coronary disease extent, and healed infarct with cardiomegaly.
Hearts with myocardial scar showed more frequent and higher scores of cardiomegaly.

Conclusions:

The extent of coronary atherosclerosis is significantly correlated with cardiac hypertrophy, independent of age and BMI.
These findings suggest a causative link between chronic ischemia and the development of cardiomegaly.
The study supports a relationship between coronary artery disease severity and increased heart muscle mass.