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Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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Renewal of Intestinal Stem Cells

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

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Adult Stem Cells

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Related Experiment Video

Updated: May 19, 2026

Protocols for Analyzing the Role of Paneth Cells in Regenerating the Murine Intestine using Conditional Cre-lox Mouse Models

Protocols for Analyzing the Role of Paneth Cells in Regenerating the Murine Intestine using Conditional Cre-lox Mouse Models

Published on: November 21, 2015

Major signaling pathways in intestinal stem cells.

Tim Vanuytsel¹, Stefania Senger, Alessio Fasano

¹Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.

Biochimica Et Biophysica Acta

|August 28, 2012

Summary

Recent advances in identifying intestinal stem cells (ISCs) and their regulatory pathways offer new therapeutic avenues for inflammatory gastrointestinal diseases and cancer. Understanding ISC interactions is key to maintaining intestinal homeostasis.

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Last Updated: May 19, 2026

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Area of Science:

Stem Cell Biology
Gastroenterology
Molecular Biology

Background:

Significant progress in stem cell biology has been driven by the identification of intestinal stem cell (ISC) markers.
Powerful transgenic mouse models have been developed to investigate stem cell physiology.

Purpose of the Study:

To review current knowledge on intestinal stem cells (ISCs).
To highlight recent advancements in ISC markers, maintenance, and differentiation pathways.
To examine ISC pathway interactions and their role in inflammatory gastrointestinal diseases.

Main Methods:

Literature review of current research on intestinal stem cells.
Analysis of pathways governing ISC maintenance and differentiation.
Examination of ISC pathway alterations in human inflammatory gastrointestinal diseases.

Main Results:

The field has identified key markers for the intestinal stem cell population.
Various pathways regulating ISC maintenance and differentiation have been elucidated.
Interactions between different stem cell-related pathways are complex and multilayered.

Conclusions:

Maintaining intestinal homeostasis involves intricate networks of interacting pathways with multiple regulatory layers.
Understanding ISC involvement in inflammatory diseases may lead to novel therapeutics for conditions like IBD and celiac disease.
Investigating ISC pathways could reveal mechanisms underlying dysplasia and cancer in chronic inflammatory conditions.