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D-dimer in preeclampsia: systematic review and meta-analysis.
Melina de Barros Pinheiro1, Daniela Rezende Garcia Junqueira, Fernanda Fonseca Coelho
1Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Brazil. tomurase@toranomon.gr.jp
Summary
Elevated D-dimer (D-Di) levels in the third trimester may indicate preeclampsia, a pregnancy complication. Further research is needed to confirm D-Di
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Maternal-Fetal Medicine
Background:
- Preeclampsia is a serious pregnancy complication characterized by hypertension and proteinuria.
- It involves fibrin deposition and maternal organ dysfunction.
- D-dimer (D-Di) is a marker for fibrin degradation and a diagnostic tool for thrombotic conditions.
Purpose of the Study:
- To systematically review and meta-analyze studies evaluating plasma D-dimer levels in preeclampsia.
- To assess the diagnostic value of D-dimer in preeclampsia compared to normotensive pregnancies.
Main Methods:
- A comprehensive literature search identified 194 publications.
- Seven studies met the eligibility criteria for systematic review and meta-analysis.
- Study quality was assessed using established recommendations.
Main Results:
- Increased plasma D-dimer levels were associated with preeclampsia in the third trimester compared to normotensive pregnancies.
- The findings suggest a potential link between D-dimer and preeclampsia.
Conclusions:
- Elevated D-dimer may be associated with preeclampsia in late gestation.
- Further comprehensive studies are required to establish D-dimer's diagnostic and prognostic role and determine appropriate cut-off values throughout pregnancy.
