Related Experiment Video
Updated: May 19, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Interrelationship between diabetes and periodontitis: a review.
1Department of Dental Surgery, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal. shaili_p@yahoo.com
JNMA; Journal of the Nepal Medical Association
|August 28, 2012
Summary
Periodontal disease and diabetes mellitus have a bidirectional relationship, where each condition exacerbates the other. Managing one may improve outcomes for the other, highlighting a cyclical association.
Area of Science:
- Oral Health
- Endocrinology
- Immunology
Background:
- Periodontal disease is a chronic oral infection with significant morbidity.
- Diabetes mellitus is a systemic disease with severe complications impacting quality and length of life.
- Periodontitis is a known complication of diabetes, affecting oral health and quality of life.
Purpose of the Study:
- To review the literature on the interrelationship between periodontal disease and diabetes mellitus.
- To explore potential common immunoregulatory connections.
- To investigate mechanisms by which periodontal infection contributes to diabetes-related inflammation.
Main Methods:
- Literature review of existing studies on diabetes and periodontal disease.
- Analysis of bidirectional associations and cyclical patterns.
- Exploration of immunoregulatory pathways and inflammatory mechanisms.
Main Results:
- A strong bidirectional relationship exists between periodontal disease and diabetes.
- The presence of one condition promotes the other.
- Management of either condition may positively impact the other.
Conclusions:
- Periodontal infection can exacerbate systemic inflammation associated with diabetes.
- Understanding the interrelationship is crucial for comprehensive patient management.
- Targeting common immunoregulatory pathways may offer therapeutic benefits.
Related Concept Videos
01:27The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
01:22Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
01:24Type II Diabetes II: Pathophysiology
PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
01:26Diabetes Mellitus: Introduction
Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and long-term...
01:26Type I Diabetes II: Pathophysiology
Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...