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G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
Published on: March 22, 2018
Large scale of human duplicate genes divergence.
1Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia. aevin@mail.cytspb.rssi.ru
Journal of Molecular Evolution
|August 28, 2012
Summary
Gene duplication and divergence drive proteome evolution. This study reveals three stages of duplicate gene evolution, with subfunctionalization and neofunctionalization as key divergence modes, favoring high gene dosage for young duplicates.
Area of Science:
- Evolutionary biology
- Genomics
- Proteomics
Background:
- Proteome complexity increases through gene duplication and divergence.
- Understanding the evolutionary stages of duplicate genes is crucial for comprehending genome evolution.
Purpose of the Study:
- To investigate the evolutionary stages of duplicate gene pairs in the human genome.
- To identify the predominant modes of functional divergence in duplicate genes.
- To explore the role of gene dosage in duplicate gene retention.
Main Methods:
- Genome-scale analysis of human duplicate gene pairs.
- Analysis of protein divergence distribution.
- Examination of functional parameters: gene expression, transcription factor targets, and protein interaction networks.
Main Results:
- Density distribution of duplicate gene pairs reveals three evolutionary stages.
- Subfunctionalization is predominant in the first divergence peak, while neofunctionalization prevails in the second.
- Young duplicate pairs exhibit higher expression levels than singleton genes, indicating the importance of gene dosage.
Conclusions:
- A prevailing route for duplicate gene evolution is high gene dosage, followed by subfunctionalization, and then neofunctionalization.
- This adaptationist model suggests evolution favors intensively used functions.
- The findings provide insights into the mechanisms driving proteome complexity and evolution.
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