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Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq
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Published on: November 13, 2017

Radiation-responsive transcriptome analysis in human lymphoid cells.

M Chiba1

  • 1Division of Medical Life Sciences, Department of Biomedical Sciences, Hirosaki University Graduate School of Health Sciences, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan. mchiba32@cc.hirosaki-u.ac.jp

Radiation Protection Dosimetry
|August 28, 2012
PubMed
Summary
This summary is machine-generated.

Ionizing radiation (IR) exposure causes DNA damage and alters gene expression. Microarray analysis revealed 65 upregulated messenger ribonucleic acid (mRNA) genes in human cells after X-ray irradiation, suggesting potential biological dosimeters.

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Area of Science:

  • Molecular Biology
  • Radiation Biology
  • Genomics

Background:

  • Ionizing radiation (IR) induces DNA damage and activates cellular signaling pathways involved in DNA repair and cell cycle regulation.
  • A deeper understanding of the molecular events following radiation exposure is crucial for comprehending irradiation effects.
  • Identifying molecular markers can aid in evaluating radiation exposure levels.

Purpose of the Study:

  • To investigate gene expression changes in response to X-ray irradiation.
  • To identify potential molecular markers for assessing radiation exposure.

Main Methods:

  • Human B lymphoblast cell line (IM-9) was exposed to X-ray irradiation (4 Gy).
  • Gene expression profiling was performed using microarray analysis.
  • Messenger ribonucleic acid (mRNA) expression levels were compared between irradiated and non-irradiated cells.

Main Results:

  • Microarray analysis identified 65 upregulated genes (>2.0-fold) in irradiated cells compared to controls.
  • A significant number of these upregulated genes exhibited an X-ray dose-dependent expression pattern.
  • The observed mRNA upregulation is a direct effect of irradiation.

Conclusions:

  • X-ray irradiation significantly alters mRNA expression profiles in human B lymphoblast cells.
  • The identified upregulated genes may serve as potential biological dosimetric markers for evaluating radiation exposure.
  • Further research can validate these findings for practical applications in radiation biodosimetry.