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Formulation design and optimization of fast dissolving clonazepam tablets by sublimation method
S B Shirsand1, Sarasija Suresh, V Kusumdevi
1Department of Pharmaceutics, H. K. E. Society's College of Pharmacy, Sedam Road, Gulbarga-585 105, India.
Indian Journal of Pharmaceutical Sciences
|August 28, 2012
Summary
Fast dissolving tablets of clonazepam were developed using sublimation to improve patient compliance. The optimized formulation demonstrated a nine-fold increase in drug release compared to conventional tablets.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Patient compliance is a significant challenge with conventional oral dosage forms.
- Fast-dissolving tablets offer an alternative to improve patient adherence and therapeutic outcomes.
Purpose of the Study:
- To develop and optimize fast-dissolving tablets of clonazepam using the sublimation method.
- To investigate the impact of croscarmellose sodium and camphor on tablet properties and drug release.
Main Methods:
- A 3(2) full factorial design was employed to study the effects of croscarmellose sodium (superdisintegrant) and camphor (subliming agent).
- Tablets were prepared by sublimation, incorporating directly compressible mannitol.
- Evaluation included hardness, friability, dispersion time, wetting time, water absorption, and in vitro drug release.
Main Results:
- The optimized formulation (5% croscarmellose sodium, 40% camphor) exhibited an in vitro dispersion time of approximately 11 seconds.
- This formulation showed a nine-fold faster drug release (t50% = 1.8 min) compared to conventional tablets (t50% = 16.4 min).
- Short-term stability studies indicated no significant changes in drug content or dispersion time.
Conclusions:
- The sublimation method is effective for preparing fast-dissolving clonazepam tablets with enhanced patient compliance.
- The optimized formulation significantly improves drug release kinetics.
- The developed fast-dissolving tablets are stable and offer a promising alternative to conventional dosage forms.
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