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Related Experiment Video

Updated: May 19, 2026

Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E
09:48

Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E

Published on: September 26, 2019

Pathophysiology of Langerhans cells.

Shweta Jaitley1, Tr Saraswathi

  • 1Department of Oral Pathology and Microbiology, K D Dental College and Hospital, Mathura, Uttar Pradesh, India.

Journal of Oral and Maxillofacial Pathology : JOMFP
|August 28, 2012
PubMed
Summary

Langerhans cells (LCs), a type of dendritic cell (DC), are crucial for initiating immune responses in the skin and oral mucosa. This review explores their origin, function, and role in various diseases.

Keywords:
Antigen presenting cellsLangerhans cellsclear cellsdendritic cells

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Last Updated: May 19, 2026

Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E
09:48

Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E

Published on: September 26, 2019

Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • Langerhans cells (LCs) are specialized dendritic cells (DCs) residing in stratified squamous epithelia, including the epidermis and oral mucosa.
  • First described in 1868, LCs constitute approximately 3% of epidermal cells and play a vital role in local immune defense.
  • They are strategically located in the suprabasal layer, positioning them to interact with pathogens and initiate immune responses.

Purpose of the Study:

  • To provide a comprehensive review of Langerhans cells (LCs).
  • To detail the origin, distribution, and demonstration methods for LCs.
  • To elucidate the mechanism of action and pathological significance of LCs.

Main Methods:

  • Literature review of existing research on Langerhans cells (LCs).
  • Synthesis of information regarding LC origin, distribution, and identification techniques.
  • Analysis of LC function as antigen-presenting cells (APCs) and their involvement in immune responses.

Main Results:

  • LCs are identified in all mammalian stratified squamous epithelia, primarily in the epidermis and oral mucosa.
  • LCs function as critical antigen-presenting cells (APCs), essential for lymphocyte recognition of microbes.
  • The review covers LC origin, distribution, demonstration, mechanism of action, and roles in pathology.

Conclusions:

  • Langerhans cells (LCs) are key players in the initiation of immune responses within epithelial tissues.
  • Understanding LCs' function is vital for comprehending local defense mechanisms and pathological conditions.
  • This review consolidates current knowledge on LCs, highlighting their importance in immunology and dermatology.