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Mean platelet volume in Type 2 diabetes mellitus
Thomas Alex Kodiatte1, Udaya Kumar Manikyam, Suraksha Bellur Rao
1Department of Pathology, Sri Devaraj Urs Medical College, Tamaka, Kolar, India. thomaskodiatte@gmail.com
Journal of Laboratory Physicians
|August 28, 2012
Summary
Mean platelet volume (MPV) is significantly higher in diabetic patients, correlating with blood glucose levels. This suggests MPV may indicate vascular complications in diabetes.
Area of Science:
- Endocrinology
- Hematology
- Metabolic Disorders
Background:
- Diabetes mellitus is a global pandemic with increasing vascular complications.
- Increased platelet activity, indicated by Mean Platelet Volume (MPV), may contribute to these complications.
- Larger platelets (higher MPV) are younger and more active.
Purpose of the Study:
- Compare MPV in diabetic versus nondiabetic individuals.
- Investigate MPV differences in diabetics with and without vascular complications.
- Determine MPV correlation with glycemic control (fasting blood glucose, HbA1c), BMI, and diabetes duration.
Main Methods:
- Measured platelet counts and MPV in 300 Type 2 diabetics and 300 controls using an automated cell counter.
- Assessed fasting blood glucose and HbA1c levels.
- Employed SPSS for statistical analysis, including Student's t-test and Pearson correlation.
Main Results:
- Diabetic patients exhibited higher MPV (8.29 ± 0.74 fl) compared to non-diabetics (7.47 ± 0.73 fl), P=0.001.
- MPV showed a strong positive correlation with fasting blood glucose, postprandial glucose, and HbA1c levels (P=0.001).
Conclusions:
- Significantly higher MPV observed in diabetic patients compared to non-diabetic subjects.
- Elevated MPV may be a cause or consequence of vascular complications in diabetes.
- MPV serves as a potential simple biomarker for assessing vascular events in diabetes.
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