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Serum concentration of visfatin is decreased in patients with chronic heart failure

Ewa Straburzyńska-Migaj1, Lucja Pilaczyńska-Szcześniak, Alicja Nowak

  • 11st Department of Cardiology, Poznań, University of Medical Sciences, Poland.

Acta Biochimica Polonica
|August 28, 2012
PubMed

Insights

Serum visfatin levels are significantly lower in patients with heart failure (HF), especially in advanced stages. These lower visfatin concentrations are independent of age or metabolic factors in HF patients.

Area of Science:

  • Cardiovascular pathophysiology
  • Metabolic syndrome
  • Adipokine research

Background:

  • Adipocytokines play an emerging role in cardiovascular disease.
  • Visfatin is a novel adipokine with potential implications in pathophysiology.
  • Understanding adipokine roles is crucial for cardiovascular health.

Purpose of the Study:

  • To compare serum visfatin levels in patients with heart failure (HF) and healthy controls.
  • To investigate the relationship between visfatin, glucose metabolism, and hsCRP in HF patients.
  • To assess visfatin levels in relation to HF severity (NYHA class).

Main Methods:

  • Study included 28 male systolic HF patients (NYHA class I-II and III-IV) and 23 controls.
  • Serum samples were analyzed for visfatin, hsCRP, glucose, and lipid metabolism parameters.
  • Insulin resistance was calculated using the Homeostasis Model Assessment (HOMA-IR).

Main Results:

  • HF patients exhibited significantly lower serum visfatin and HDL-cholesterol compared to controls (p≤0.01).
  • Significant differences in mean levels of visfatin, hsCRP, glucose, HOMA-IR, and HDL-cholesterol were observed across groups.
  • Visfatin levels were notably lower in HF patients with more advanced NYHA classes.

Conclusions:

  • Serum visfatin concentrations are significantly reduced in patients with systolic HF.
  • Lower visfatin levels in HF are particularly pronounced in advanced NYHA classes.
  • Visfatin levels in HF are independent of age, anthropometric, and metabolic parameters.
Abstract

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