Related Experiment Video

Updated: May 19, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Childhood wheezing phenotypes and FeNO in atopic children at age 8

R J P van der Valk1, D Caudri, O Savenije

  • 1Department of Pediatrics, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|August 29, 2012
PubMed

Insights

Fractional exhaled Nitric Oxide (FeNO) levels at 8 years old correlate with specific childhood wheezing phenotypes, particularly in children with allergies. This finding highlights FeNO

Area of Science:

  • Pediatric respiratory medicine
  • Allergy and immunology
  • Biomarker research

Background:

  • Fractional exhaled Nitric Oxide (FeNO) is a key biomarker for eosinophilic airway inflammation.
  • Five distinct wheezing phenotypes in children have been identified through longitudinal latent class analysis, differing in onset and prognosis.

Purpose of the Study:

  • To investigate the relationship between FeNO levels at ages 4 and 8 years and various childhood wheezing phenotypes.
  • To explore the role of atopy in the association between FeNO and wheezing phenotypes.

Main Methods:

  • Utilized data from the prospective PIAMA birth cohort study in the Netherlands.
  • Identified five wheezing phenotypes using yearly respiratory health questionnaires up to age 8.
  • Employed weighted linear regression to analyze associations between FeNO and wheezing phenotypes.

Main Results:

  • FeNO at 4 years was elevated in intermediate and persistent wheeze phenotypes compared to never/transient wheeze.
  • Significant differences in FeNO at 8 years were observed across all wheezing phenotypes, with highest levels in persistent, intermediate, and late-onset wheeze.
  • The increase in FeNO from 4 to 8 years was significantly higher in intermediate and late-onset wheezers, especially those with allergic sensitization.

Conclusions:

  • FeNO measured at 8 years is significantly associated with specific wheezing phenotypes.
  • This association is primarily evident in children with allergic sensitization.
  • FeNO may serve as a valuable indicator for identifying children with persistent or late-onset wheezing and allergic tendencies.
Abstract

More Related Videos

Auricular Acupressure as an Adjuvant Treatment for Wheezing in Stable Chronic Obstructive Pulmonary Disease02:34

Auricular Acupressure as an Adjuvant Treatment for Wheezing in Stable Chronic Obstructive Pulmonary Disease

Published on: May 10, 2024

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography08:58

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

Published on: July 10, 2018

Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma