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Adenosine triphosphate-binding cassette transporter G2 expression in endometriosis and in endometrium from patients

Sachiko Matsuzaki¹, Claude Darcha

¹CHU Clermont-Ferrand, CHU Estaing, Chirurgie Gynécologique, Clermont-Ferrand, France. sachikoma@aol.com

Fertility and Sterility

|August 29, 2012

Abstract

Objective:

To investigate adenosine triphosphate (ATP)-binding cassette transporter G2 (ABCG2) expression in endometriosis and in samples of endometrium from patients with and without endometriosis.

Design:

Prospective study.

Setting:

University hospital.

Patient(S):

Patients with and without endometriosis.

Intervention(S):

Endometrial and endometriotic tissues obtained throughout the menstrual cycle.

Main Outcome Measure(S):

Density of ABCG2(+) microvessels, density of CD31(+) microvessels.

Result(S):

No statistically significant differences in the density of ABCG2(+) microvessels were observed between endometrium of patients with and without endometriosis in the proliferative phase and early, middle, and late secretory phases. The density of ABCG2(+) microvessels was statistically significantly higher in the menstrual endometrium of patients with endometriosis compared with patients without endometriosis. The density of ABCG2(+) microvessels was reduced in the ectopic endometrium compared with matched eutopic endometrium except in cases of deep infiltrating endometriosis. The density of ABCG2(+) microvessels was statistically significantly higher in deep infiltrating endometriosis compared with ovarian endometriosis and red and black peritoneal lesions throughout the menstrual cycle.

Conclusion(S):

ABCG2 is strongly expressed in the endothelial cells of microvessels of eutopic endometrium, and the density of ABCG2(+) microvessels is reduced in ectopic endometrium except in cases of deep infiltrating endometriosis. ABCG2(+) microvessels may represent an integral part of the pathophysiology of deep infiltrating endometriosis.

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