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Fixation-off sensitivity.

F Brigo1, F Rossini, A Stefani

  • 1Department of Neurological, Neuropsychological, Morphological and Movement Sciences, Section of Clinical Neurology, University of Verona, Italy. dr.francescobrigo@gmail.com

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|August 29, 2012
PubMed
Summary
This summary is machine-generated.

Fixation-off sensitivity (FOS) is an EEG abnormality triggered by eye closure, often seen in childhood epilepsy. While it can cause seizures, its inherent risk for epilepsy is considered low.

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Area of Science:

  • Neurology
  • Epileptology
  • Clinical Neurophysiology

Background:

  • Fixation-off sensitivity (FOS) is a phenomenon characterized by EEG abnormalities upon cessation of central vision.
  • It manifests as posterior or generalized epileptiform discharges consistently occurring after eye closure.

Purpose of the Study:

  • To define and differentiate Fixation-off sensitivity (FOS) from related phenomena like scotosensitivity and eye closure sensitivity.
  • To describe the clinical and EEG characteristics of FOS and its association with various epilepsy types.

Main Methods:

  • Review of clinical and EEG data from patients with and without epilepsy, focusing on responses to eye closure.
  • Differential diagnosis of FOS, scotosensitivity, and eye closure sensitivity based on established criteria.

Main Results:

  • FOS is observed in idiopathic childhood occipital epilepsies, symptomatic epilepsies, and even in non-epileptic individuals.
  • It is distinguished from scotosensitivity (darkness-induced) and eye closure sensitivity (triggered by the act of closing eyes).
  • FOS is associated with occipital hyperexcitability but has a presumed low intrinsic epileptogenic potential.

Conclusions:

  • Fixation-off sensitivity is a distinct phenomenon related to visual fixation cessation.
  • While potentially indicative of underlying hyperexcitability, FOS itself has a low risk of causing epilepsy.