Related Experiment Video

Updated: May 19, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

[Alliance against MDRO: safeguarding antibiotics]

J Carlet1, C Rambaud, C Pulcini

  • 1jeancarlet@gmail.com

Annales Francaises D'Anesthesie Et De Reanimation
|August 29, 2012
PubMed

Insights

Antibiotic resistance is a growing crisis with few new drugs available. An alliance of professionals and policymakers is urgently needed to combat multidrug-resistant organisms (MDROs).

Area of Science:

  • Microbiology
  • Public Health
  • Pharmacology

Context:

  • Escalating antibiotic resistance poses a significant threat to global health.
  • The current pipeline for new antibiotics is critically insufficient to meet future demands.
  • Existing treatments are failing for common infections, increasing risks for complex medical procedures.

Purpose:

  • To highlight the urgent need for action against multidrug-resistant organisms (MDROs).
  • To introduce a newly formed alliance dedicated to combating antibiotic resistance.
  • To outline proposed measures and emphasize professional consensus.

Summary:

  • Antibiotic resistance is dramatically increasing, with a severe shortage of new antibiotics expected.
  • Excessive antibiotic use across human and animal sectors drives this resistance.
  • An alliance involving healthcare professionals, consumers, managers, and politicians has formed to address MDROs.

Impact:

  • Increased risk for surgeries, transplants, and immunosuppressive therapies.
  • Potential for common infections to become untreatable.
  • Urgent need for coordinated action and policy changes to preserve antibiotic efficacy.

More Related Videos

Antibiotic Dereplication Using the Antibiotic Resistance Platform10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Antibiotic Selection00:57

Antibiotic Selection

Overview
Inhibitors of Bacterial Protein Synthesis01:25

Inhibitors of Bacterial Protein Synthesis

Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...