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Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Tabebuialdehydes A-C, cyclopentene dialdehyde derivatives from the roots of Tabebuia rosea
Jirapast Sichaem1, Sutin Kaennakam, Pongpun Siripong
1Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Abstract:
Two new cyclopentene dialdehydes, tabebuialdehydes A and B (1 and 2) and a new dihydrocyclopenta[c]furan monoaldehyde, tabebuialdehyde C (3), along with ten known compounds were isolated from the roots of Tabebuia rosea. The structures of all isolated compounds were elucidated through their physical properties and by the use of spectroscopic methods, as well as comparisons with previous literature data. Moreover, all isolated compounds were evaluated for their cytotoxicity (KB and HeLa cell lines). Compounds 6, 7 and 9 showed significant cytotoxicity against both KB and HeLa cells with IC(50) values of 1.35 and 1.15, 0.53 and 0.77, 1.79 and 0.73μg/mL, respectively.
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