Related Experiment Video
Updated: May 19, 2026

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
Published on: March 28, 2025
[Treatment of hydrocephalus]
1Klinik für Neurochirurgie, Universitätsklinikum des Saarlandes, Homburg/Saar, Kirrbergerstraße, Homburg/Saar, Deutschland. Michael.Kiefer@uks.eu
Clinical/Methodical Issue:
Modern treatment of hydrocephalus. STANDARDS OF CLINICAL AND RADIOLOGICAL METHODS: Clinically: shunting and endoscopy. Radiologically: MRT, CCT.
Methodical Innovations:
Important innovations are gravitational valves and neuroendoscopy standing for new challenges in preoperative imaging and for sufficient interpretation of postoperative imaging.
Performance:
G-valves reduce the complication rate (especially overdrainage) in shunting significantly. While lacking appropriated clinical studies, the UK Shunt Registry still provides the best comparison between shunting and neuroendoscopy, after which the long-term revision rates of both methods are identical. The perioperative risk of endoscopic surgery seems to be higher than for shunts.
Achievements:
The superiority of the G-valves in chronic hydrocephalus in comparison with other valves has recently been demonstrated in a class 1 evidence-based study. The neuroendoscopy, has been,-in the absence of a contraindications -, indicated by a guidelines' committee of the German Society of Neurosurgery as method of choice in occlusive hydrocephalus alternatively to shunting.
Practical Recommendations:
Preoperatively, to clarify etiology, comorbidity, and surgical planning, MRI is preferable; with planned neuroendoscopy as high-resolution detailed MRI of access-trajectory and region of interest. In post-operative CT or MRI (after endoscopic procedures always MRI) a differentiation between (sub-)acute and chronic hydrocephalus is important for correct interpretation of imaging: a normalization of ventricular size is physiological only in (sub-)acute hydrocephalus, in chronic hydrocephalus, yet, sign of overdrainage. In chronic hydrocephalus, ventricles shrink usually only marginally. Solely, better delineated, vertex-near cisternae are there evidence of sufficient drainage.
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