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Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Gallbladder01:17

Gallbladder

The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins the common...
Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...

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Related Experiment Video

Updated: May 19, 2026

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb
04:50

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb

Published on: January 17, 2025

Gallbladder cancer, a vanishing disease?

S Alexander1, V E P P Lemmens, S Houterman

  • 1Department of Surgery, Màxima Medical Center Academy, PO Box 7777, 5500 MB Veldhoven, Eindhoven, The Netherlands. s.alexander@elisabeth.nl

Cancer Causes & Control : CCC
|August 29, 2012
PubMed
Summary

Gallbladder cancer (GBC) incidence has significantly decreased over three decades in the Netherlands. Treatment and survival rates for GBC remained stable despite declining GBC rates.

Related Experiment Videos

Last Updated: May 19, 2026

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb
04:50

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb

Published on: January 17, 2025

Area of Science:

  • Gastroenterology
  • Oncology
  • Epidemiology

Background:

  • Gallbladder cancer (GBC) is a rare but serious gastrointestinal malignancy.
  • Understanding trends in GBC incidence, treatment, and outcomes is crucial for public health strategies.
  • Population-based studies provide valuable insights into disease patterns over time.

Purpose of the Study:

  • To evaluate trends in the incidence of gallbladder cancer (GBC) over three decades.
  • To analyze changes in treatment modalities for GBC during the study period.
  • To assess the impact of these trends on GBC patient survival.

Main Methods:

  • A retrospective population-based study design was employed.
  • Data were collected from the Dutch Eindhoven Cancer Registry, covering 1975-2008.
  • Trend analyses were performed on incidence, treatment, and survival data for 659 GBC patients.

Main Results:

  • Standardized GBC incidence dramatically decreased in both females and males.
  • Resection rates for GBC declined over the study period.
  • Five-year survival for GBC remained stable at approximately 10%.

Conclusions:

  • The age-standardized incidence of GBC has significantly declined over the past 30 years.
  • Potential contributing factors include increased cholecystectomies for gallstones and H. pylori treatment.
  • While incidence decreased, GBC treatment and survival rates showed limited change.