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Related Experiment Video

Updated: May 19, 2026

Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics
07:38

Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics

Published on: May 17, 2019

Tissue microarray construction for salivary gland tumors study.

Felipe Paiva-Fonseca1, Oslei-Paes de Almeida, Ana-Lúcia-Carrinho Ayroza-Rangel

  • 1Department of Oral Diagnosis Oral Pathology Section, Piracicaba Dental School, State University of Campinas - São Paulo - Brazil.

Medicina Oral, Patologia Oral Y Cirugia Bucal
|August 29, 2012
PubMed
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Tissue microarray (TMA) blocks effectively represent salivary gland tumors (SGTs) for molecular studies, though cystic tumors pose sampling challenges. This method allows for representative tissue analysis with minimal loss.

Area of Science:

  • Oncology
  • Pathology
  • Biotechnology

Background:

  • Salivary gland tumors (SGTs) are diverse neoplasms requiring robust methods for molecular analysis.
  • Tissue microarray (TMA) technology offers a way to efficiently study large numbers of tissue samples.

Purpose of the Study:

  • To evaluate the design, construction, and utility of TMA blocks for studying SGTs.
  • To assess the representativeness and limitations of TMA in SGT analysis.

Main Methods:

  • Formalin-fixed, paraffin-embedded SGTs (n=238) were used to construct TMA blocks.
  • Manual tissue arrayer was employed, taking three representative cores (1.0-3.0mm) from each tumor.
  • Characteristics of the resulting TMA cores were analyzed.

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A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
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A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Related Experiment Videos

Last Updated: May 19, 2026

Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics
07:38

Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics

Published on: May 17, 2019

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
09:32

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Main Results:

  • Twelve TMA blocks containing representative neoplastic cylinders were successfully created.
  • Sampling difficulties were noted for SGTs with abundant cystic spaces, such as mucoepidermoid carcinoma and Warthin tumor.
  • Estimated tissue damage and loss during TMA construction was 3.7%.

Conclusions:

  • TMA blocks can provide representative areas of SGTs for molecular studies with minimal tissue loss.
  • Tumors characterized by extensive cystic spaces present challenges for adequate TMA sampling.