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Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: May 19, 2026

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
08:02

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Published on: January 7, 2019

[Cartilage regeneration].

M O Brix1, C Chiari

  • 1Universitätsklinik für Orthopädie, Medizinsche Universität Wien, Wien.

Zeitschrift Fur Orthopadie Und Unfallchirurgie
|August 29, 2012
PubMed
Summary
This summary is machine-generated.

Articular cartilage damage causes pain and functional impairment, risking early joint replacement. This article reviews diagnostic methods and surgical repair techniques like mosaicplasty and cell-based therapies for cartilage restoration.

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Isolation of Chondrocytes and Chondroprogenitors Using Fibronectin Adhesion and Migratory Assay

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Related Experiment Videos

Last Updated: May 19, 2026

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
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Published on: January 7, 2019

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
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Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Isolation of Chondrocytes and Chondroprogenitors Using Fibronectin Adhesion and Migratory Assay
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Isolation of Chondrocytes and Chondroprogenitors Using Fibronectin Adhesion and Migratory Assay

Published on: October 4, 2024

Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Biomedical Engineering

Context:

  • Articular cartilage damage presents significant clinical challenges, leading to pain, reduced function, and diminished quality of life.
  • Early joint replacement is a potential consequence of untreated or poorly managed cartilage lesions.
  • Current treatment landscape includes established methods and emerging cell-based approaches.

Purpose:

  • To provide a comprehensive overview of preoperative diagnosis and classification systems for articular cartilage lesions.
  • To present and discuss various cartilage repair procedures, including mosaicplasty, bone marrow-stimulating techniques, and cell-based methods.
  • To outline the indications for different cartilage repair strategies.

Summary:

  • The article details diagnostic approaches for cartilage defects, emphasizing classification systems.
  • It elaborates on surgical interventions such as mosaicplasty, bone marrow stimulation, and cell therapies.
  • Key indications and patient selection criteria for each procedure are discussed.

Impact:

  • Improved understanding of cartilage lesion diagnosis and treatment options for clinicians.
  • Guidance on selecting appropriate surgical interventions for patients with articular cartilage damage.
  • Potential for enhanced patient outcomes and quality of life through effective cartilage repair.