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Updated: May 19, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Encapsulation of contrast imaging agents by polypropyleneimine-based dendrimers
S Balieu1, C Cadiou, A Martinez
1Institut de Chimie Moléculaire de Reims (ICMR), UMR CNRS No. 6229, UFR Sciences, Université Reims-Champagne-Ardenne, Reims, France.
Abstract:
Polypropyleneimines (PPIs) functionalized by glycerol-based entities are prepared and characterized by diffusion-ordered spectroscopy NMR. Showing low cytotoxicity against MRC5 fibroblasts, their encapsulation capacities of gadolinium complexes was evaluated. T(1) measurements were performed to determine the relaxivity of the encapsulated gadopentetate dimeglumine (GdBOPTA) in dendrimers of fourth and fifth generation (GD-PPI-4 and GD-PPI-5). Comparison of the GdBOPTA relaxivity and the relaxivity of GdBOPTA-loaded dendrimers showed a slight increase of the gadolinium chelate relaxivity.

