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Related Concept Videos

Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...
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Defenses Against Pathogens and Herbivores

Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
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Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
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Related Experiment Video

Updated: May 19, 2026

Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus
12:29

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Published on: April 19, 2017

Complement Attack against Aspergillus and Corresponding Evasion Mechanisms.

Cornelia Speth1, Günter Rambach

  • 1Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Fritz-Pregl-Straße 3, 6020 Innsbruck, Austria.

Interdisciplinary Perspectives on Infectious Diseases
|August 29, 2012
PubMed
Summary
This summary is machine-generated.

Invasive aspergillosis is a deadly fungal infection. This review explores how the complement system interacts with Aspergillus, detailing fungal evasion tactics and complement

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Last Updated: May 19, 2026

Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus
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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

Area of Science:

  • Medical Mycology
  • Immunology
  • Infectious Diseases

Background:

  • Invasive aspergillosis presents a significant mortality risk, especially in immunocompromised individuals.
  • Increasing cases underscore the need to understand innate immunity's role in combating fungal infections.
  • The complement system is a critical component of innate immunity against fungal pathogens.

Purpose of the Study:

  • To review the complex interactions between Aspergillus and the complement system.
  • To elucidate the mechanisms by which Aspergillus activates complement and the system's antifungal effects.
  • To identify strategies employed by Aspergillus to evade complement-mediated immune responses.

Main Methods:

  • Literature review focusing on studies investigating Aspergillus-complement system interactions.
  • Analysis of research detailing complement activation pathways by Aspergillus.
  • Examination of evidence for Aspergillus complement evasion mechanisms.

Main Results:

  • Aspergillus can activate the complement system through various pathways.
  • The complement system exerts direct antifungal effects against Aspergillus.
  • Aspergillus employs sophisticated strategies to evade complement recognition and destruction.

Conclusions:

  • Understanding Aspergillus's complement evasion mechanisms is crucial for developing effective antifungal therapies.
  • The interplay between Aspergillus and complement highlights potential targets for improving host defense in immunocompromised patients.