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Melatonin: bone metabolism in oral cavity
Fanny López-Martínez1, Patricia N Olivares Ponce, Miriam Guerra Rodríguez
1Department of Advance General Dental Master, School of Dentistry, Universidad Autónoma de Nuevo León, Hidalgo 2425-403, Col. Obispado, Monterrey, NL, Mexico.
International Journal of Dentistry
|August 29, 2012
Summary
Melatonin may inhibit bone resorption by affecting osteoclast function and down-regulating RANK-L. This suggests melatonin
Area of Science:
- Bone Biology and Metabolism
- Endocrinology
- Biomaterials Science
Background:
- Bone tissue remodeling involves a continuous balance between resorption and formation.
- Melatonin possesses antioxidant and free radical scavenging properties.
- Previous research suggests melatonin may influence osteoclast activity.
Purpose of the Study:
- To investigate the potential of melatonin to inhibit bone resorption.
- To explore melatonin's role in osteoclastogenesis and its clinical implications.
Main Methods:
- Review of existing literature on melatonin's effects on bone metabolism.
- Analysis of studies investigating melatonin's impact on osteoclast function and RANK-L expression.
Main Results:
- Melatonin, particularly at pharmacological doses, appears to decrease bone mass resorption.
- This effect is associated with the suppression and down-regulation of RANK-L.
- Melatonin's action on osteoclastogenesis suggests a potential osteogenic effect.
Conclusions:
- Melatonin demonstrates potential as a therapeutic agent for conditions involving bone loss, such as osteoporosis.
- Its ability to inhibit bone resorption and promote bone formation holds clinical significance.
- Melatonin may also be beneficial as a bioactive surface for medical implants.
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